HASSANEIN, Waleed,KHAYAL, Tamer,ELBETANONY, Ahmed,LEZBERG, Paul,CECERE, Giovanni,SOUSA, Dennis,HANSEN, Elizabeth
申请号：
AU2019275587
公开号：
AU2019275587A1
申请日:
2019.12.04
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2019275587A120200102.pdf#####ABSTRACT The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of an organ care system heart perfusion device to evaluate 1) the overall perfusion status of an isolated heart, 2) the metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved of oxygen and to metabolize/utilize lactate for energy production when they are well perfused with oxygen.
