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Stable melphalan liquid injectable formulations
专利权人:
Krishnamurthy Toppaladoddi;Nagaraju Dasari;Rizwan Ahmed;Shivakumar Pradeep;Guptha Chinni Guru Deva
发明人:
Shivakumar Pradeep,Krishnamurthy Toppaladoddi,Rizwan Ahmed,Guptha Chinni Guru Deva,Nagaraju Dasari
申请号:
US16513758
公开号:
US10682326B1
申请日:
2019.07.17
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to a stable, non-aqueous liquid, formulation consisting essentially of melphalan, or a pharmaceutical acceptable salt thereof; and one or more solvents selected from group consisting of dimethyl acetamide, polyethylene glycol, ethanol, propylene glycol, dimethyl sulfoxide, N-methylpyrrolidone and glycerol; wherein said formulation is free of antioxidants, organic acid and added chloride ions; and the process for preparation thereof.
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