A method of manufacturing a medical device that reduces the platelet adhesion of a surface that comes into contact with blood by irradiating at least the surface of a titanium or titanium alloy substrate that has been machined with an electron beam, and a specific pretreatment method or electron beam With this irradiation method, the adhesion of platelets on the surface that comes into contact with blood is reduced, and the formation of minute dents (so-called craters) that may occur due to electron beam irradiation is suppressed A method of manufacturing a device is provided.少なくとも切削加工されたチタンまたはチタン合金基材表面に電子線を照射して、血液と接触する表面の血小板付着性を減少させる医療用機器を製造する方法、また、特定の前処理方法や電子線の照射方法を用いて、血液と接触する表面の血小板付着性を減少させ、かつ、電子線照射に起因して起こることがある表面の微小な窪み（いわゆるクレーター）の形成が抑制される医療用機器を製造する方法を提供する。
