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Monocyclic pyridine derivative
专利权人:
EISAI R&D MANAGEMENT CO. LTD.
发明人:
Funasaka Setsuo,Okada Toshimi,Tanaka Keigo,Nagao Satoshi,Ohashi Isao,Yamane Yoshinobu,Nakatani Yusuke,Karoji Yuki
申请号:
NZ71110114
公开号:
NZ711101A
申请日:
2014.02.18
申请国别(地区):
NZ
年份:
2018
代理人:
摘要:
The present invention discloses a compound represented by the following formula (IA) or a pharmaceutically acceptable salt thereof wherein n represents 0 to 2 A represents an arylene group or a heteroarylene group G represents a single bond, an oxygen atom or CH2 E represents a nitrogen-containing non-aromatic heterocycle R1 represents an alkoxy group, an alkoxy alkoxy group or the like R2 represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group, a hydroxy alkyl group, a nitrogen-containing non-aromatic heterocyclic group or the like R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like and R4 represents a C1-6 alkyl group, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom. The compound of formula (IA) or a pharmaceutically acceptable salt thereof has an FGFR1 inhibitory action, an FGFR2 inhibitory action and an action to selectively inhibit an FGF/FGFR signal against a VEGF/KDR signal, particularly, a selective FGFR1, FGFR2 or FGFR3 inhibitory action. The compound of formula (IA) of the present invention or a pharmaceutically acceptable salt thereof has a potential use for a therapeutic agent for stomach cancer, non-small-cell lung carcinoma including lung squamous cell carcinoma, bladder cancer or endometrial cancer.
来源网站:
中国工程科技知识中心
来源网址:
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