SANGHAVI, SNEHA,MORRIS, ERICK,HALILOVIC, ENSAR,CLAPERON, AUDREY,MARAGNO, ANA LETICIA,MOUJALLED, DONIA,MISTRY, PRAKASH,WANG, YOUZHEN,PORTER, DALE,MAACKE, HEIKO,GENESTE, OLIVIER,POMILIO, GIOVANNA,WEI, A
申请号：
ARP170102054
公开号：
AR109125A1
申请日:
2017.07.21
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: a combination which comprises (a) an inhibitor of bcl-2 of formula (1), in which X and y represent a carbon Atom or a nitrogen Atom.Not understanding that can simultaneously represent two carbon Atoms and two nitrogen Atoms and a¹ a-squared, together with those Atoms that are United,Form a Heterocyclic Aromatic or non Aromatic substituted het optionally comprising 5, 6 or 7 members in the Ring which may contain, in addition to nitrogen or represented by X, andOne to three heteroatoms selected irrespective of Oxygen, Sulfur and NitrogenUnderstanding that the Nitrogen in question can be replaced by a group that represents a hydrogen Atom,A c₁₋₆ linear or branched alkyl group or a Group - C (o) - O - ALK in that ALK is a linear or branched alkyl group c₁₋₆,Or a¹ a-squared independently of each other and represent a hydrogen Atom, a linear or branched polihaloalquilo c₁₋₆,A linear or branched alkyl group c₁₋₆ or cycloalkyl T represents a hydrogen Atom,A linear or branched alkyl group c₁₋₆ optionally substituted with one to three Halogen Atom, an alkyl group c₁₋₄ - nr¹r²,Or an alkyl group c₁₋₄ - or⁶ r¹ R² independently of each other and represent a hydrogen Atom or a linear or branched alkyl group c₁₋₆,Or r¹ and R² form with the nitrogen Atom to which they are United heterocicloalquilo r³ c₁₋₆ represents a linear or branched alkyl group, a group alquenilo c₂₋₆ linear or branched.A group Alquinilo c₂₋₆ linear or branched, a cycloalkyl Group, a Group c₃₋₁₀ cycloalkyl alkyl c₁₋₆ in which the other is linear or branched alkyl group, a heterocicloalquilo,An aryl or heteroaryl Group a Group, provided that one or more of the carbon Atoms of the previous groups, or their potential SubstituentMay be deuterated r⁴ represents an aryl Group, a cycloalkyl group or a heteroaryl Group, a linear or branched alkyl group c₁₋₆,Where one or more of the carbon Atoms of the previous groups, or their potential substituents may be deuterated r⁵ represents a hydrogen Atom or a HalogenA
