A compound having the formula (II): ** Formula ** or a pharmaceutically acceptable salt, clathrate, solvate, stereoisomer or tautomer thereof, wherein: R1 is substituted pyridyl； R2 is H, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclyl alkyl, substituted or unsubstituted aralkyl or substituted or unsubstituted cycloalkylalkyl； and R3 is substituted or unsubstituted C1-8 alkyl； wherein the term "substituted" denotes a substitution with any of the substituents recited in the subsequent claims or with halogen； I rent； hydroxyl； alkoxy； alkoxyalkyl； Not me； alkylamino； carboxy； nitro； cyano； thiol； thioether； imine； imide； amidine； guanidine； enamine； aminocarbonyl； acylamino； phosphonate； phosphine； thiocarbonyl； sulfonyl； sulfone； sulfonamide； ketone； aldehyde； ester； urea； urethane； oxime； hydroxyl amine； alkoxyamine； aralkoxyamine； N-oxide； hydrazine； hydrazide； hydrazone； azide； isocyanate； isothiocyanate； cyanate； thiocyanate； oxygen (>； = O)； B (OH) 2, O (alkyl) aminocarbonyl； cocloalkyl, which may be monocyclic or polycyclic condensed or non-condensed； heterocyclyl； which can be monocyclic or polycyclic condensed or non-condensed； condensed or non-condensed monocyclic or polycyclic aryl or heteroaryl； aryloxy； aralkyloxy； heterocyclyloxy or heterocyclyl alkoxy.Un compuesto que tiene la fórmula (II):**Fórmula** o una sal, clatrato, solvato, estereoisómero o tautómero farmacéuticamente aceptable del mismo, donde: R1 es piridilo sustituido； R2 es H, alquilo C1-8 sustituido o sin sustituir, cicloalquilo sustituido o sin sustituir, heterociclilo sustituido o sin sustituir, heterociclilalquilo sustituido o sin sustituir, aralquilo sustituido o sin sustituir o cicloalquilalquilo sustituido o sin sustituir； y R3 es alquilo C1-8 sustituido o sin sustituir； donde el término "sustituido" denota una sustitución con cualquiera de los sustituyentes recitado
