LYNCH Rosemary,ЛИНЧ Роузмэри,CANSFIELD Andrew David,КЭНСФИЛД Эндрю Дэвид,HARDY Daniel Paul,ХАРДИ Дэниел Пол,FEUTRILL John Thomas,ФИУТРИЛЛ Джон Томас,ADREGO Rita,АДРЕГО Рита,ELLARD Katie,ИЛЛАРД Кейти,L
申请号：
RU2014109748
公开号：
RU0002609208C2
申请日:
2012.10.05
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmaceutics.SUBSTANCE: invention relates to compounds of formula (I) and their pharmaceutically acceptable salts. In formula (I) m is equal to 1 o equals 1 or 2 each R1 is independently selected from group consisting of H and unsubstituted C1-6alkyl two R1 are possibly combined to form, together with ring, to which they are bonded, 8-oxa-3-azabicyclo[3.2.1]octane-3-yl or 3-oxa-8-azabicyclo[3.2.1]octane-8-yl ring T1 is phenyl, where T1 is substituted by group N(R5a)C(O)N(R5bR5) and T1 is optionally additionally substituted with one or more R6, which are identical or different R6 is halogen each of R5a, R5b represents H R5 represents H T2 and C1-6alkyl, where C1-6alkyl is optionally substituted with one or more R8, which are identical or different R8 represents halogen or OR9 R9 represents H T2 is unsubstituted and selected from group consisting of phenyl, pyridyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, oxetanyl or tetrahydrofuranyl Ra and Rb are selected to obtain one of formulae (Ik)–(Ip)or Ra, Rb, T1 are selected to obtain formula (Iq)R14, R14a, R14b, R14c are independently selected from group consisting of H halogen or unsubstituted C1-6alkyl. Compounds of formula (I) possess mTOR inhibiting activity. Invention also relates to pharmaceutical composition containing compounds of formula (I), use of compounds for making drug and to method of treating.EFFECT: novel compounds of formula (I) are obtained, which have mTOR inhibitor activity, which can be used for treating or preventing mTOR related diseases and disorders.16 cl, 15 tbl, 82 exИзобретение относится к соединениям формулы (I) и их фармацевтически приемлемым солямВ формуле (I) m равно 1 о равно 1 или 2 каждый R1 независимо выбран из группы, состоящей из Н и незамещенного С1-6алкила возможно два R1 объединены с образованием, вместе с кольцом, к которому они присоединены, 8-окса-3-азабицикло[3.2.1]октан-3-ильного или 3-окса-8-азабицикло[3.2.1]октан-8-ильного кольца Т1 представляет собой фенил
