Jan Peter Van Pijkeren,Alan Attie,Mark Keller,Jee-Hwan Oh
申请号：
US16443405
公开号：
US20190351020A1
申请日:
2019.06.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods and microorganisms for systemically introducing a polypeptide in the bloodstream of a subject. The methods of the invention include administering into the gastrointestinal tract of a subject a bacterium configured to express and produce and release the polypeptide. The bacterium is administered in an amount effective to introduce the polypeptide in the bloodstream of the subject, preferably in a detectable amount. The microorganisms of the invention include lactic acid bacteria, such as Lactobacillus reuteri, that comprise a recombinant gene configured to express a polypeptide to be systemically introduced.
