In one embodiment, an X-ray diagnostic apparatus includes an X-ray source, an X-ray detector, an arm, and processing circuitry. The arm supports the X-ray source and the X-ray detector. The processing circuitry identifies a three-dimensional running direction of a blood vessel of an object from a plurality of images that are obtained by using the X-ray source and the X-ray detector to image the object from at least two different angles, and controls positions of the X-ray source and the X-ray detector by using the arm in such a manner that a target position of the blood vessel is imaged from the at least two different directions determined depending on the three-dimensional running direction.