METHODS OF INDUCING AN IMMUNE RESPONSE WITH COMPOSITIONS COMPRISING A NEISSERIA MENINGITIDIS 741 PROTEIN

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专利权人:

GLAXOSMITHKLINE BIOLOGICALS SA

发明人:

Mariagrazia PIZZA

申请号：

US14739985

公开号：

US20150273044A1

申请日:

2015.06.15

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH2-A-[—X-L-]n-B—COOH where X is an amino acid sequence, L is an optional linker amino acid sequence, A is an optional N-terminal amino acid sequence, B is an optional C-terminal amino acid sequence, and n is an integer greater than 1. Proteins where each of the n-X— moieties shares sequence identity to each other —X— moiety, the protein is a ‘tandem protein’.

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