Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide

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专利权人:

ALKERMES INC.

发明人:

ALVAREZ JUAN,CHAMOUN JEAN,LOSEY HEATHER C.

申请号：

NZ63084813

公开号：

NZ630848A

申请日:

2013.06.06

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Disclosed is a fusion protein comprising a mucin-domain polypeptide linked to at least one active protein wherein the mucin-domain polypeptide has at least 4 tandem amino acid repeating units of at least 8 amino acids in length per tandem repeating unit, wherein the active protein is selected from: IL-1Ra and exendin-4 and wherein the half-life of the fusion protein is increased by at least two fold as compared to the half-life of the corresponding active protein that is not fused to the mucin-domain polypeptide.

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