MUTÉINE MUR6S4TR DE TRAIL À DOUBLE CIBLE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION

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专利权人:

Ltd;Chengdu Huachuang Biotechnology Co.

发明人:

CHEN, Shouchun,XU, Qi,YAN, Juan,HUANG, Xianzhou,WEI, Lijia,HU, Haiyang

申请号：

EP15906481

公开号：

EP3348578A4

申请日:

2015.10.22

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention belongs to the field of genetic engineering drugs, and provides a mutein MuR6S4TR of TRAIL, and a preparation method and use thereof. The N-terminal positions 2-11 of the amino acid sequence of the mutein consist of the transmembrane peptide sequence RRRRRR (R6) and the binding sequence AVPI of the apoptosis inhibitor XIAP, the positions 12-169 are the TRAIL protein peptide segment (124-281 aa), and the specific sequence is as shown in SEQ ID NO: 2.

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中国工程科技知识中心

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http://www.ckcest.cn/home/