Robin Barbour,Kate Dora Games Thiel,Tarlochan S. Nijjar
申请号：
US16856855
公开号：
US20200317763A1
申请日:
2020.04.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides monoclonal antibody 5C1 and related antibodies. The 5C1 antibody binds to an epitope within residues 118-126 of α-synuclein. The antibodies of the invention are useful, for example, for treating and/or diagnosing disorders associated with α-synuclein, particularly accumulation of α-synuclein deposits. Such disorders include Lewy body diseases, such as Parkinson's disease, Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer' s disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy (MSA).
