The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.本發明提供一種調節猬狀信號傳導途徑之活性的方法。詳言之，本發明提供一種抑制由諸如Ptc功能喪失、猬狀功能獲得、平滑化功能獲得或Gli功能獲得之表型造成之異常生長狀態的方法，該方法包含使細胞與足夠量之式I化合物接觸。
