Compounds derived from 2 - oxo - 1,2,3,4 - Tetrahidroquinolina Inhibitors, aldosterone sitasa (CYP11B2 and CYP11B1)； a process for preparing them and Pharmaceutical composition； method of treatment or prophylaxis； and use for the Treatment or prophylaxis of renal disease or chronic congest heart failure Ivo, among others.
MOHR, PETER,LIU, YONGFU,AEBI, JOHANNES,AMREIN, KURT,HORNSPERGER, BENOIT,KUHN, BERND,MAERKI, HANS P.,MAYWEG, ALEXANDER V.,ZHOU, MINGWEI,FANTASIA, SERENA MARIA,SCALONE, MICHELANGELO,TAN, XUEFEI
申请号：
CL2014000663
公开号：
CL2014000663A1
申请日:
2014.03.19
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 A3 and n are as described herein, compositions including the compounds and methods of using the compounds. The compounds of the present invention are useful as inhibitors of aldosterone synthase. The compounds may be used, for example, in the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.<；p>；COMPUESTOS DERIVADOS DE 2-OXO-1,2,3,4-TETRAHIDROQUINOLINA, INHIBIDORES DE ALDOSTERONA SINTASA CYP11B2 O CYP11B1； PROCESO DE PREPARACIÓ；N； COMPOSICIÓ；N FARMACÉ；UTICA； Y USO PARA TRATAMIENTO O PROFILAXIS DE ENFERMEDAD RENAL CRÓ；NICA, FALLO CARDIACO CONGESTIVO, HIPERTENSIÓ；N, ALDOSTERONISMO PRIMARIO Y SÍ；NDROME DE CUSHING.<；/p>；
