Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti solvent in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating drying transporting of particles can be avoided because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.