The present invention relates to novel 5-[trimethoxyphenyl]-l-thiomethyl-l-N-aryl-l,4-dien-3-ones of general formula 4, analogs, derivatives and salts, thereof, Wherein R4 is selected from a group consisting of -C6H5, C6H4-p -OCH3, C6H4-p-Cl, C6H4F, C6H11 and CH2C6H5. The compounds prepared are useful as anitileishmanial compounds and compounds have shown excellent in-vitro results and the in-vivo tests in hamster models further showed promising activity. The synthesis of these compounds is simple, economically feasible, environmentally friendly and easily processable.[IN-DEL-2007-02456A]
