The present invention provides an improved method for reducing the risk orseverity of restenosis following cardiac angioplasty. The method includesadministering to a target vessel region, a morpholino antisense compoundhaving uncharged phosphorus-containing backbone linkages, and spanning thestart codon of a human c-myc mRNA. Also disclosed are novel antisensecompounds and compositions, and a method for assaying the effectiveness ofantisense delivery and uptake to a target vessel region.
