OH SEI-RYANG,AHN KYUNG SEOP,LEE SU UI,SHIN IN SIK,SHIN NA-RAE,LEE TAE-SUK,KANG JONGKOO,JUNG YOUNG-SIK,HAN YONG-HAE,SOHN KI YOUNG
申请号：
IN201627009227
公开号：
IN201627009227A
申请日:
2016.03.16
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating asthma and a functional health food composition for preventing or treating asthma. The monoacetyldiacylglycerol compound of the present invention inhibits the expression of IL 4 in EL 4 cells which are mouse T cell lymphoma cells reduces hypersensitivity of airway in an asthma induced animal model and inhibits the infiltration of inflammatory cells into the bronchial tube. In addition the compounds of the present invention inhibit the generation of IgE in the serum and bronchoalveolar lavage fluid have an excellent effect of inhibiting the expression of Th2 cytokines (IL 4 IL 5 and IL 13) in the lung thereby overcome side effects of the currently used therapeutic agents for asthma have no toxicity and exhibit a superior therapeutic effect and thus can be useful as a composition for preventing treating and alleviating asthma.
