ENZYCHEM LIFESCIENCES CORPORATION;KOREA RESEARCH INSTITUTE OF BIO SCIENCE AND BIOTECHNOLOGY
发明人:
Sei-Ryang Oh,Kyung Seop Ahn,Su Ui Lee,In Sik Shin,Na-Rae Shin,Tae-Suk Lee,JongKoo Kang,Young-Sik Jung,Yong-Hae Han,Ki Young Sohn
申请号：
US14912920
公开号：
US10098864B2
申请日:
2014.08.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating asthma, and a functional health food composition for preventing or treating asthma. The monoacetyldiacylglycerol compound of the present invention inhibits the expression of IL-4 in EL-4 cells, which are mouse T cell lymphoma cells, reduces hypersensitivity of airway in an asthma-induced animal model, and inhibits the infiltration of inflammatory cells into the bronchial tube. In addition, the compounds of the present invention inhibit the generation of IgE in the serum and bronchoalveolar lavage fluid, have an excellent effect of inhibiting the expression of Th2 cytokines (IL-4, IL-5, and IL-13) in the lung, thereby overcome side effects of the currently used therapeutic agents for asthma, have no toxicity, and exhibit a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating asthma.
