The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to ZIKV glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing ZIKV activity, thus providing a means of treating or preventing ZIKV infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the ZIKV for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.本發明提供結合至ZIKV醣蛋白之單株抗體或其抗原結合片段、包含該等抗體之醫藥組成物、及使用方法。本發明之該等抗體可用於抑制或中和ZIKV活性，因此提供一種治療或預防人類之ZIKV感染之方式。在一些實施例中，本發明提供用於防止病毒附著及/或進入至宿主細胞的一或多種結合至ZIKV之抗體之用途。本發明之該等抗體可預防性或治療性地使用，且可單獨或與一或多種其他抗病毒藥劑或疫苗組合使用。
