The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to Ebola virus glycoproteins, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing Ebola virus activity, thus providing a means of treating or preventing Ebola virus infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the Ebola virus for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.本發明係提供與抗伊波拉病毒醣蛋白結合之單株抗體或其抗原結合片段，包括此抗體之醫藥組成物及使用方法。本發明之抗體可用於抑制或中和伊波拉病毒活性，因此提供治療或預防人類中伊波拉病毒感染之方法。在某些實施例中，本發明係提供一或多種與伊波拉病毒結合之抗體用於預防伊波拉病毒黏附及/或進入宿主細胞之用途。本發明之抗體可用於預防上或治療上且可單獨或與一或多種其他的抗病毒劑或疫苗組合使用。
