PROBLEM TO BE SOLVED: To provide compositions for treatment of various skin conditions caused by loss of hyaluronan, such as skin dehydration, lack of skin elasticity, skin roughness, lack of skin tautness, skin striae and/or pregnancy stretch marks, skin paleness and skin wrinkles.SOLUTION: There is provided a fluid composition comprising uncrosslinked matrix polymers that include an additional stabilizing component, e.g., mannitol, that reduces or prevents degradation of uncrosslinked matrix polymers such as hyaluronan that are soluble and rapidly cleared from the body by in vivo degradation pathways.COPYRIGHT: (C)2015,JPO&INPIT【課題】ヒアルロナンの損失による、皮膚の脱水症、皮膚の弾性欠如、皮膚の粗さ、皮膚の緊縮性欠如、皮膚線条及び/又は妊娠線、皮膚の蒼白、並びに皮膚の皺等の様々な皮膚状態の治療のための組成物の提供。【解決手段】可溶性であり、in vivo分解経路によって体から急速に消失するヒアルロナンのような非架橋マトリックス重合体の分解を低減または阻害する安定化構成成分、例えばマンニトールをさらに含む非架橋マトリックス重合体を含む流体組成物。【選択図】なし
