An object of the present invention is to provide a hollow fiber membrane that can achieve stable performance in response to increases in blood flow rate and filtration rate by optimizing a structure of a dense layer on an inner surface of the hollow fiber membrane. A hollow fiber membrane including a dense layer at least on an inner surface side of the hollow fiber membrane, in which when the inner surface of the hollow fiber membrane is observed under an atomic force microscope, a plurality of groove-like recesses oriented in a lengthwise direction of the hollow fiber membrane are observed, an aspect ratio defined as a ratio of a length to a width of each of the recesses is greater than or equal to 3 and less than or equal to 30, a yield strength of the hollow fiber membrane in a dry state is greater than or equal to 30 g/filament, and a breaking elongation is less than or equal to 20%/filament.
