COBURN, Craig A.,MCCAULEY, John A.,LUDMERER, Steven W.,LIU, Kun,VACCA, Joseph P.,WU, Hao,HU, Bin,SOLL, Richard,SUN, Fei,WANG, Xinghai,YAN, Man,ZHANG, Chengren,ZHENG, Mingwei,ZHONG, Bin,ZHU, Jian
申请号：
ES10756840
公开号：
ES2573088T3
申请日:
2010.03.25
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound having the structural formula (I): ** Formula ** and / or a pharmaceutically acceptable salt thereof, in which: each R1 is independently selected from the group consisting of hydrogen, halogen, -OR3a, -CN , - (CH2) 0-6C (O) R3； -CO2R3a, -C (O) N (R3a) 2, -SR3a, -S (O) R3a, -S (O2) 3a, - (CH2) 0-6 (Ra3) 2, -N (R3a) SO2R3a, -N (R3a) CO2R3a, -N (R3a) C (O) 3, -N (R3a) COR3a, -N (R3a) C (O) N (R3a), C1-6 alkyl, C3-8 carbocycle containing from 0 to 3 heteroatoms chosen from N, O and S, and phenyl, and C1-6 alkyl, C3-8 carbocycle and phenyl are substituted with 0 to 3 substituents independently selected from the group consisting of hydrogen, halogen, -OR3a, -CN, -CO2R3a, -C (O) N (R3a) 2, -N (R3a) 2, -N (R3a) CO2R3a, -SR3a, -S (O) R3a, -S (O2) R3a , -N (R3a), SO2R3a, N (R3a) CO2R3a, -N (R3a) C (O) N (R3a), C1-6 alkyl, -O-C1-6 alkyl, -S-C1-6 alkyl and C3-8 cycloalkyl； u is 0 to 4, each R3 is independently selected from the group consisting of hydrogen, C1-6 alkyl, -OH, -O-C1-6 alkyl and C3-8 cycloalkyl, and each R3a is independently selected from the group consisting of hydrogen, C1-6 alkyl and C3-8 cycloalkyl； each R2 is independently selected from the group consisting of hydrogen, halogen, -OR4a, -CN, -CO2R4a, -C (O) R4a, -C (O) N (R4a) 2, -N (R4a) 2, - N (R4a) COR4, -N (R4a) CO2R4a, -N (R4a) C (O) N (R4a), -N (R4a) SO2R4a, -SR4a, -S (O) R4a, -S (O2) R4a , C1-6 alkyl substituted with 0 to 4 R4 and C3-8 cycloalkyl substituted with 0 to 4 R4, v is 0 to 4, each R4 is independently selected from the group consisting of hydrogen, -OH, C1-6 alkyl and C3-8 cycloalkyl； each R4a is independently selected from the group consisting of hydrogen, C1-6 alkyl and C3-8 cycloalkyl； wherein said ** Formula ** and said ** Formula ** are taken in conjunction with one of said R1 substituent and one of said R2 substituents to form a 5- to 9-membered carbocyclic ring containing 1 or 2 heteroatoms independently selected from the group consisting of N, O and S, represented by a group
