FANG, Larry Yun,HARRIS, David,KRISHNA, Gopal,MOTON, Allen, E., Jr.,PRESTIPINO, Russell C.,STEINMAN, Marc,WAN, Jiansheng,WASKIN, Hetty Anne
申请号：
AU2014265059
公开号：
AU2014265059A1
申请日:
2014.11.20
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014265059A120141211.pdf#####ABSTRACT The present application provides novel compositions comprising posaconazole and a polymer wherein the composition has a glass transition temperature 5 temperature (Tg) of less than about 110*C. The application also describes compositions comprising posaconazole and a polymer having a bulk density of greater than about 0.4 mg/mL. The application also describes compositions comprising posaconazole and a polymer which provide an exposure (AUCtf) of at least about 10,000 ng.hr/mL when administered to a patient in a fasted state. 10 The application also describes a novel process for preparing these compositions. The preferred polymer is HPMCAS. Preferably the composition is an extruded material.Sheet 517 cmr 0< 0~ 0 0 0 0 0p (IWI u) Uo0e4uG3uo3 Bwseld OIozBu0BSOd
