In alternative embodiments the invention provides methods for treating ameliorating or protecting (preventing) an individual or a patient against a disease an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence； or an expression vehicle a vector a recombinant virus or equivalent having contained therein a paracrine encoding nucleic acid or gene and the expression vehicle vector recombinant virus or equivalent can express the paracrine encoding nucleic acid or gene in a cell or in vivo； and administering or delivering the paracrine polypeptide encoding nucleic acid or gene operatively linked to a transcriptional regulatory sequence or the expression vehicle vector recombinant virus or equivalent to an individual or a patient in need thereof thereby treating ameliorating or protecting (preventing) the individual or patient against the disease infection or condition responsive to an increased paracrine polypeptide level.
