University of Pittsburgh - Of the Commonwealth Sys
发明人:
ROSS, Ted, M.,CARTER JR., Donald, M.,CREVAR, Corey, J.
申请号：
HK16100529.2
公开号：
HK1212708A
申请日:
2016.01.18
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates is described. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2012. Optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides are described. Condon-optimized nucleic acid sequences encoding the HA polypeptides are also described. Methods of eliciting an immune response against influenza virus in a subject are also described.
