University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人:
Ted M. Ross,Corey J. Crevar
申请号：
US16119501
公开号：
US20180371025A1
申请日:
2018.08.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein is the generation of optimized HIN1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
