INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE CHIMICO-FARMACEUTICA - ICCF
发明人:
NICHITA CORNELIA,NICHITA CORNELIA,NEAGU GEORGETA,NEAGU GEORGETA,VULTURESCU VIRGINIA CRISTIANA,VULTURESCU VIRGINIA CRISTIANA,ALBULESCU RADU NICOLAE AUREL,ALBULESCU RADU NICOLAE AUREL,NITA SULTANA,NIŢĂ
申请号：
RO201001024
公开号：
RO127270B1
申请日:
2010.10.28
申请国别(地区):
RO
年份:
2013
代理人:
摘要：
The invention relates to a product with antioxidant effect and to a process for preparing the same. According to the invention, the product comprises 2.19...4.00% flavonoids expressed as rutin, 2.36...6.0% polyphenolcarboxylic acids expressed as caffeic acid and 3.07...13.96% polyphenols expressed as gallic acid. The process claimed by the invention consists in extracting and processing the plant material obtained from the species Crataegus monogyna Jacq. by ultrasound treating the dry plant material comminuted for 20...50 min, at a temperature of 20...40°C, followed by 2...4 cycles of extraction at the solvent reflux temperature for 2...3.5 h at a 1:1 ratio with a solvent consisting of methyl alcohol and demineralized water in a ratio of 1:1, the extract being then cooled down to 5°C, filtered, bleached with 1% active carbon and processed by vacuum concentration, at a temperature of 40...60°C, until a ratio of 1:4...1:10, as compared with the initial volume, is reached, then it is precipitated while stirring, for 15...45 min, with methanol acidified up to a pH value of 2.5...5.8, is maintained at 5°C for 48...72 h and is centrifuged at 4°C for 20 min to separate the precipitated product which is filtered, washed with acetone and ethyl alcohol and then dried to finally obtain a greenish-brown product having an antioxidant activity of 95...99.5%.Invenţia se referă la un produs cu acţiune antioxidantă şi la un procedeu pentru obţinerea acestuia. Produsul conform invenţiei cuprinde flavonoide 2,19...4,00% exprimate în rutin, acizi polifenolcarboxilici 2,36...6,0% exprimaţi în acid cafeic, şi polifenoli 3,07...13,96% exprimaţi în acid galic. Procedeul conform invenţiei constă din extracţia şi prelucrarea materialului vegetal obţinut de la specia Crataergus monogyna Jacq., prin ultrasonarea materialului vegetal uscat şi mărunţit timp de 20...50 min, la 20...40°C, după care urmează 2...4 cicluri de extracţie la temperatura de reflux a solventului timp de 2...3,5 h, la
