Robert P. Kimberly;Kimihisa Ichikawa;Tong Zhou;William J. Koopman
发明人:
Tong Zhou,Kimihisa Ichikawa,Robert P. Kimberly,William J. Koopman
申请号：
US13621383
公开号：
US08715668B2
申请日:
2012.09.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
An antibody of the invention interacts with human DR5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-DR5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated. Methods and uses for the antibodies are detailed including treatment of apoptosis-related disease and treatment of dysregulated cell growth.
