The present invention provides antibodies and related molecules that bind to chemokine receptor 4 (CXCR4). The invention further provides antibody-drug conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and anti-CXCR4 antibody-drug conjugates for the treatment of a disorder associated with CXCR4 function or expression (e.g., cancer), such as colon, RCC, esophageal, gastric, head and neck, lung, ovarian, pancreatic cancer or hematological cancers.本發明提供結合於趨化激素受體4(CXCR4)之抗體及相關分子。本發明進一步提供包含此類抗體之抗體-藥物結合物、編碼抗體之核酸及獲得此類抗體之方法。本發明進一步關於使用此等抗體及抗CXCR4抗體-藥物結合物之治療方法，其用於治療與CXCR4功能或表現相關之病症(例如癌症)，諸如結腸癌、RCC、食道癌、胃癌、頭頸部癌、肺癌、卵巢癌、胰臟癌或血液癌症。
