Young Min Kim,Dae Jin Kim,Sung Min Bae,Chang Ki Lim,Se Chang Kwon,Gwan Sun Lee
申请号：
US13796135
公开号：
US10071166B2
申请日:
2013.03.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed are a protein conjugate with improved in vivo duration and stability and the use thereof. The protein conjugate includes a physiologically active polypeptide, a non-peptide polymer and an immunoglobulin Fc fragment. Since the three components are covalently linked, the protein conjugate has extended in vivo duration and enhanced stability for the physiologically active polypeptide. The protein conjugate maintains the in vivo activity at relatively high levels and remarkably increases the serum half-life for the physiologically active polypeptide, with less risk of inducing undesirable immune responses. Thus, the protein conjugate is useful for developing long-acting formulations of various polypeptide drugs.
