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FORME CRISTALLINE D'INHIBITEUR DE TRANSCRIPTASE INVERSE
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
MAGUIRE, COURTNEY K.
申请号:
CA2882947
公开号:
CA2882947A1
申请日:
2013.09.20
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
The retrovirus designated human immunodeficiency virus (HIV), particularly the strains known as HIV type- 1 (HIV -I) and type-2 (HIV -2), have been etiologically linked to the immunosuppressive disease known as acquired immunodeficiency syndrome (AIDS). HIV seropositive individuals are initially asymptomatic but typically develop AIDS related complex (ARC) followed by AIDS. Affected individuals exhibit severe immunosuppression which makes them highly susceptible to debilitating and ultimately fatal opportunistic infections. The invention is directed to a novel crystalline form of the RT inhibitor 3-chloro-5-({1-[( 4-methyl-5 -oxo-4,5 -dihydro-1H -1,2, 4-triazol-3 -yl)methyl]-2-oxo-4-( trifluoromethy 1 )-1,2-dihydropyridin-3 -yl) oxy )benzonitrile used in the treatment HIV infection and AIDS.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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