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Crystalline form of reverse transcriptase inhibitor
专利权人:
メルク・シャープ・アンド・ドーム・コーポレーション
发明人:
マグワイヤー,コートニー,ケー,マグワイヤー,コートニー,ケー
申请号:
JP2015534567
公开号:
JP6387349B2
申请日:
2013.09.20
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The retrovirus designated human immunodeficiency virus (HIV), particularly the strains known as HIV type-1 (HIV-I) and type-2 (HIV-2), have been etiologically linked to the immunosuppressive disease known as acquired immunodeficiency syndrome (AIDS). HIV seropositive individuals are initially asymptomatic but typically develop AIDS related complex (ARC) followed by AIDS. Affected individuals exhibit severe immunosuppression which makes them highly susceptible to debilitating and ultimately fatal opportunistic infections. The invention is directed to a novel crystalline form of the RT inhibitor 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile used in the treatment HIV infection and AIDS.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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