Federico Mingozzi,Xavier Anguela,J. Fraser Wright,Katherine A. High
申请号：
US14360151
公开号：
US10640785B2
申请日:
2012.11.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides viral vector formulations and methods of uses thereof for delivery of transgenes or therapeutic nucleic acids to human subjects. The formulations include a vector and suitable amounts of empty capsids, viral genome-containing capsids, or viral capsid proteins which are optionally chemically or structurally modified and which bind to neutralizing anti-AAV antibodies thereby reducing or preventing antibody-mediated clearance of the vector, but still allowing the genome-containing (therapeutic) vector to transduce target cells and achieve therapeutic gene transfer.
