The present disclosure provides T-cell modulatory multimeric polypeptides that comprise an immunomodulatory polypeptide that exhibits reduced binding affinity to a cognate co-immunomodulatory polypeptide. A T-cell modulatory multimeric polypeptide is useful for modulating the activity of a T cell, and for modulating an immune response in an individual.本揭露提供T細胞調節多聚體多肽，其包含免疫調節多肽，該免疫調節多肽表現出降低的與同源共免疫調節多肽之結合親和力。T細胞調節多聚體多肽可用於調節T細胞之活性，並用於調節個體之免疫反應。
