SHANGHAI INSTITUTE OF MATERIA MEDICA; CHINESE ACADEMY OF SCIENCES
发明人:
DING, Ke,DING, Jian,CHAN, Shingpan,GENG, Meiyu,REN, Xiaomei,XIE, Hua,TU, Zhengchao,CHEN, Yi
申请号：
SG11201704244S
公开号：
SG11201704244SA
申请日:
2015.11.18
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The invention discloses a kind of 2- amino-metadiazine compounds and its pharmaceutical composition and applications, the structure of 2- amino-metadiazine compounds is as shown in I, in formula, R1, R2, R3, R4, R5, X, Y, Z, W, definition as described in specification and claims, such compound can effectively inhibit the growth of kinds of tumor cells, and inhibiting effect is generated to EGFR and IGF1R protease, it can be used for preparing anti-tumor drug, and existing drug Gefitinib can be overcome, the drug resistance of the inductions such as Tarceva, there is selectivity to tumour especially wild type non-small cell lung cancer, with good pharmacokinetic property.
