The present invention is represented by the following general formula (1), which has an action of activating glucokinase in liver and pancreatic β cells, and is useful as a preventive and / or therapeutic agent for diseases caused by hyperglycemia such as diabetes. It is to provide a novel compound. General formula (1) [wherein the A ring represents a nitrogen-containing 5- to 10-membered heteroaryl group, R1 and R2 may be the same or different, and may be a hydrogen atom, a halogen atom, a halo C1-6 alkyl group, C6 -10 aryl group, cyano group, C1-6 alkyl group which may have a substituent, C2-6 alkenyl group which may have a substituent, etc., and R3 has a hydrogen atom and a substituent A C1-6 alkyl group or the like which may be present, and R4 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group which may have a substituent or the like], or a salt thereof, or Their solvates. [Chemical 1]本発明は、肝臓及び膵臓β細胞のグルコキナーゼの活性化作用を有し、高血糖に起因する疾患、例えば糖尿病の予防及び／又は治療剤として有用な、以下の一般式（１）で表される新規化合物を提供することである。一般式(1)[式中、A環は窒素含有5-10員へテロアリール基を示し、R1、R2は、同一又は異なってもよく、水素原子、ハロゲン原子、ハロC1-6アルキル基、C6-10アリール基、シアノ基、置換基を有してもよいC1-6アルキル基、置換基を有してもよいC2-6アルケニル基等を示し、R3は、水素原子、置換基を有してもよいC1-6アルキル基等を示し、R4は、水素原子、ハロゲン原子、置換基を有してもよいC1-6アルキル基等を示す]で表されるスピロインドリン化合物若しくはその塩、又はそれらの溶媒和物。【化１】
