#$%^&*AU2005203228B220120329.pdf#####Abstract Synergistic therapies for the treatment of vitiligo are provided. The major therapies for the Treatment of vitiligo - a pigmentary disorder characterized by patchy depigmentation of ；kin are Psoralens plus UV-A, steroids. Basic fibroblast growth (bFGF) peptide lotion or surgical procedures. Psoralens plus UV-A is effective in about 50% of cases, steroids are limitedly effective only in fast spreading cases of vitiligo and often reoccurs on stoppage of treatment. Surgical treatment is the last resort for vitiligo therapy, when all other therapies failed. It is limitedly effective. Basicfibroblast growth factor peptide(s) lotion was developed as a new mode of therapy for the treatment of vitiligo. It went through successfully various phases of clinical trials in India and is allowed to be marketed by the drug controller general (India). It is effective in 80% of stable and in segmental vitiligo. Here data are provided and demonstrated that combinatorial treatment of vitiligo by local application of bFGF peptide(s) lotions in association with psoralens and UV-A, or steroids or surgical procedures produce synergistic response and that the rate of repigmentation increases synergistically and more efficacious results are obtained than with any of them alone. Any Combinatorial therapy comprising the local application of bFGF peptide lotion on the vitiligo patch in combination with any other therapies for the treatment of vitiligo also may act synergistically.
