A computer-implemented system for supporting an imaging operation and related methods. The system comprises one or more input interfaces (IN) for receiving input data including an input image procured by an imaging apparatus (IA) of a target location (ROI) in a conduit (VS) of an object (OB). The conduit includes a target substance (CA) and the target substance (CA) is propagatabale in the conduit towards the target location. A pretrained-machine learning component (MLC2) is configured to process the input data to obtain output data indicative of an arrival of the said target substance at said target location. An output interface (OUT) outputs said output data.
