sequence optimized body capable of specifically binding to a cd123 epitope and a cd3 epitope, bispecific diabody capable of specifically binding to a cd123 epitope and a cd3 epitope, pharmaceutical composition, and use of the pharmaceutical composition
EZIO BONVINI,GURUNADH REDDY CHICHILI,LESLIE S. JOHNSON,LING HUANG,PAUL A. MOORE,RALPH FROMAN ALDERSON
申请号：
BR112016003417
公开号：
BR112016003417A2
申请日:
2014.08.20
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Summary sequence optimized body capable of specifically binding to a cd123 epitope and a cd3 epitope, bispecific diabody capable of specifically binding to a cd123 epitope and a cd3 epitope, pharmaceutical composition, and use of the pharmaceutical composition to The present invention is directed to the sequence optimized bispecific monovalent cd123 x cd3 diabodies which are capable of binding simultaneously to cd123 and cd3, and the uses of such diabodies in the treatment of hematologic malignancies. 1/1resumo diacorpo otimizado por sequência capaz de se ligar especificamente a um epitopo de cd123 e a um epitopo de cd3, diacorpo biespecífico capaz de se ligar especificamente a um epitopo de cd123 e a um epitopo de cd3, composição farmacêutica, e uso da composição farmacêutica a presente invenção é direcionada aos diacorpos monovalentes biespecíficos cd123 x cd3 otimizados pela sequência que são capazes de se ligarem simultaneamente a cd123 e cd3, e aos usos de tais diacorpos no tratamento de malignidades hematológicas. 1/1
