ALDERSON, Ralph,BONVINI, Ezio,CHICHILI, Gurunadh,HUANG, Ling,JOHNSON, Leslie,MOORE, Paul
申请号:
TN2016000046
公开号:
TN2016000046A1
申请日:
2014.08.20
申请国别(地区):
TN
年份:
2017
代理人:
摘要:
The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific for an epitope of CD3 and one binding site specific for an epitope of gpA33 (i.e., a "gpA33 x CD3bi-specific monovalentdiabody"). The present invention also is directed to bispecific monovalent diabodies that comprise an immunoglobulin Fe Domain (''bispecific monovalent Fe diabodies") and are composed of three polypeptide chains and which possess at least one binding site specific for an epitope of gpA33 and one binding site specific for an epitope of CD3 (i.e., a "gpA33 x CD3 bi-specific monovalent Fe diabody"). The bi-specific monovalent diabodies and bi-specific monovalent F c diabodies of the present invention are capable of simultaneous binding to gpA33 and CD3. The invention is directed to pharmaceutical compositions that contain such bi-specific monovalent diabodies or such bi-specific monovalent Fe diabodies. The invention is additionally directed to methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.