<;P>;PROBLEM TO BE SOLVED: To provide a method for screening calorie restriction (CR) mimetics. <;P>;SOLUTION: There is provided the method for screening including steps of: carrying out a reporter assay using a reporter vector containing a consensus sequence found on the upstream side of a gene in which expression is activated by the CR, a promoter, and a reporter gene; comparing the expression level of the reporter gene in the presence of a test substance with that in the absence of the test substance; and selecting the test substance raising the expression level of the reporter gene as the CR mimetics. <;P>;COPYRIGHT: (C)2011,JPO&INPIT