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specific local intestinal distribution of adsorbents, alone or in combination with degradation molecules
专利权人:
DA VOLTERRA
发明人:
HELENE HUGUET,ANTOINE ANDREMONT
申请号:
BRPI0712098
公开号:
BRPI0712098A2
申请日:
2007.05.18
申请国别(地区):
BR
年份:
2012
代理人:
摘要:
SPECIFICALLY LOCAL INTESTINAL DISTRIBUTION OF ADSORVENTS, ALONE OR IN COMBINATION WITH DEGRADATION MOLECULES. Compositions which deliver adsorbents, alone or in combination with active drug "degradation molecules" in a specific local manner to the gut, and which eliminate or at least decrease the concentration of undesired residual material within the gut, are disclosed. Methods of treatment using the compositions are also disclosed. Material to be eliminated may include residual active antibiotics, metabolites, bacterial or other toxins, and drugs that cause side effects in the gastrointestinal tract. Adsorbents may be formulated in capsules, tablets or any acceptable pharmaceutical composition, and are ideally designed to specifically release the adsorbents in a programmed manner at a specific site of the intestinal tract. Programmed distribution prevents adsorbents from interfering with the normal absorption process of a given molecule after oral absorption until it reaches the lower part of the small intestine. The compositions may be used to adsorb, and therefore remove, any residual drug, metabolite thereof, or bacterial toxin following oral or parenteral administration which would otherwise cause adverse effects on the lower intestine and / or colon.DISTRIBUIçãO INTESTINAL ESPECìFICA LOCAL DE ADSORVENTES, SOZINHOS OU EM COMBINAçãO COM MOLéCULAS DE DEGRADAçãO. Composições que distribuem adsorventes, sozinhos ou em combinação com "moléculas de degradação" de fármaco ativa em uma maneira específica local ao intestino, e que eliminam ou pelo menos diminuem a concentração de material indesejado residual dentro do intestino, são reveladas. Métodos de tratamento usando as composições são também revelados. O material a ser eliminado pode incluir antibióticos ativos residuais, metabólitos, toxinas bacteriais ou outras, e fármacos que causam efeitos colaterais no trato gastrointestinal. Os adsorventes podem ser formulados em cápsulas, comprimidos ou qualquer composição
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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