Huguet, Hélène-Céline,Andremont, Antoine,Tsapis, Nicolas,Fattal, Elias
申请号：
ES11176876
公开号：
ES2660234T3
申请日:
2007.05.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
An orally administrable pharmaceutical composition for intestinal site-specific adsorbent release, comprising: a) an adsorbent selected from the group consisting of activated carbon, clays, talc, silica and resins, and b) a specific site delivery system to release the adsorbent into the ileum or colon, where the delivery system is coated with a coating material or a combination of coating materials selected from: cellulosic polymers such as hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl methylcellulose, hydroxypropyl methylcellulose acetate , hydroxypropylmethyl cellulose phthalate, methyl cellulose, ethyl cellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate trimellitate and sodium carboxymethyl cellulose； a tercopolymer of methacrylic acid, methyl acrylate and methyl methacrylate； vinyl polymers and copolymers such as polyvinylpyrrolidone, vinyl acetate, vinyl acetate phthalate, vinyl acetate and crotonic acid copolymer, and ethylene-vinyl acetate copolymer； azo or amylose polymers； and lacquer； wherein for one hundred percent by weight of the composition, the adsorbent is in the range of about 10 to about 99%.Una composición farmacéutica administrable por vía oral para la liberación intestinal de sitio específico de adsorbentes, que comprende: a) un adsorbente seleccionado del grupo que consiste en carbón activado, arcillas, talco, sílice y resinas, y b) un sistema de suministro de sitio específico para liberar el adsorbente en el íleon o en el colon, donde el sistema de suministro está recubierto con un material de recubrimiento o una combinación de materiales de recubrimiento seleccionados de: polímeros celulósicos tales como hidroxipropilcelulosa, hidroxietilcelulosa, hidroximetilcelulosa, hidroxipropilmetilcelulosa, acetato succinato de hidroxipropilmetilcelulosa, ftalato de hidroxipropilmetilcelulosa, metilcelulosa, etilcelulosa, acetato de celulosa, acetato ftalato de celulosa, acetato trimelit
