ДЗЕ РЕГЕНТС ОФ ДЗЕ ЮНИВЕРСИТИ ОФ КАЛИФОРНИЯ (US); ИНК. (US);ОТОНОМИ;ОТОНОМИ, ИНК. (US)
发明人:
ЛИХТЕР Джей (US),ФОЛЛЬРАТ Бенедикт (US),ТРЭММЕЛ Эндрю М. (US),ДЮРОН Сергио Г. (US),ПЬЮ Фабрис (US),ДЕЛЛАМЭРИ Луис А. (US),Е Цян (US),ЛЕБЕЛ Карл (US),СКАЙФ Майкл Кристофер (US),ХАРРИС Джеффри П. (US)
申请号：
RU2010147298/15
公开号：
RU2010147298A
申请日:
2009.04.21
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A pharmaceutical composition intended for the treatment of a disease or condition of the ear by introducing into the tympanic cavity on the membrane of the round ear window or near it, the composition includes:! a copolymer of polyoxyethylene and polyoxypropylene； ! active substance； ! wherein the composition provides a sustained release of the active substance into the inner ear over a period of time of at least 7 days. ! 2. The composition according to claim 1, characterized in that the active substance is an immunomodulator, a vasopressin antagonist, an ion channel modulator, a neurokinin receptor antagonist, a serotonin reuptake inhibitor, a NMDA receptor modulator, an prostaglandin analog, a drug acting on the central nervous system, a modulator GABA receptor, cytotoxic agent, antioxidant, glutamate receptor modulator or calcineurin inhibitor. ! 3. The composition according to claim 1, characterized in that the active substance is a drug acting on the central nervous system. ! 4. The composition according to claim 3, characterized in that the drug acting on the central nervous system is diazepine. ! 5. The composition according to claim 1, characterized in that the active substance is an ion channel modulator. ! 6. The composition according to claim 5, characterized in that the ion channel modulator is a retigabin. ! 7. The composition according to claim 1, characterized in that the active substance is a modulator of glutamate receptors. ! 8. The composition according to claim 1, characterized in that the pharmaceutical composition is an acceptable thermally reversible gel for the ears. ! 9. The composition according to claim 1, characterized in that the copolymer of polyoxye�1. Фармацевтическая композиция, предназначенная для лечения заболевания или состояния уха путем введения в барабанную полость на мембрану круглого окна уха либо около нее, при этом композиция включает: ! сополимер полиоксиэтилена и полиоксипропилена； ! активное вещество； ! при этом к
