MORALES CORONA, JUAN,MONDRAGON LOZANO, RODRIGO,ALVAREZ MEJIA, ANA LAURA,MORALES GUADARRAMA, JUAN CARLOS AXAYACATL,RIOS CASTANEDA, LUIS CAMILO,DIAS RUIZ, MARIA DE LOS ANGELES ARACELI,CRUZ CRUZ, GUILLER
申请号：
EP07747213
公开号：
EP2164078A4
申请日:
2007.06.01
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The purpose of the present invention is to demonstrate that semiconducting and non-biodegradable implants made with polypyrrole and polyethylenglycol copolymers and iodine-doped and plasma-synthesised pyrrole polymers, have a neuroprotector effect and induce the reconnection of the spinal cord after an injury this effect was proved in a model involving a complete section of the spinal cord in rats the results o the functional evaluation demonstrated 5 times greater recovery in animals implanted with the polypyrrole-polyethylenglycol copolymer compared with the control group which only underwent a complete section of the spinal cord in addition, the functional recovery of the group with iodine-doped polypyrrole was ten times greater compared to the control group in the histological study various inflammatory and immune cells were identified at the injury site in the three experimental groups with and without implants and the integration of the polymers in the nervous tissue of the spinal cord was also observed finally, no respiratory, renal or skin infections, adverse effects or rejection of the biomaterials were found in any of the animals.
