Vivo temporary control of the variable-activated matrix-degrading enzyme

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专利权人:

ハロザイム インコーポレイテッド

发明人:

ギルバート・エイ・ケラー,グレゴリー・アイ・フロスト

申请号：

JP2010549679

公开号：

JP5709531B2

申请日:

2009.03.06

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading enzymes. The methods and combinations permit temporary in-vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or “ECM”). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/