PLETTENBURG, OLIVER,HOFMEISTER, ARMIN,LORENZ, KATRIN,BRENDEL, JOACHIM,LOHN, MATTHIAS,WESTON, JOHN
申请号：
NZ57798007
公开号：
NZ577980A
申请日:
2007.12.19
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein are cycloalkylamine substituted isoquinolone derivatives of formula (I) and (I'), wherein the substituents are as defined within the specification, processes for their preparation, medicaments comprising said compounds and uses thereof. Said compounds are useful in the treatment and/or prevention of diseases related to the inhibition of Rho-kinase and/or of Rho-kinase mediated phosphorylation of myosin light chain phosphatase, such as hypertension, pulmonary hypertension, ocular hypertension, retinopathy, glaucoma, peripheral circulatory disorder, peripheral arterial occlusive disease (PAOD), coronary heart disease, angina pectoris, heart hypertrophy, 30 heart failure, ischemic diseases, ischemic organ failure (end organ damage), fibroid lung, fibroid liver, liver failure, nephropathy, renal failure, fibroid kidney, renal glomerulosclerosis, organ hypertrophy, asthma, chronic obstructive pulmonary disease (COPD), adult respiratory distress syndrome, thrombotic disorders, stroke, cerebral vasospasm, cerebral ischemia, pain, neuronal degeneration, spinal cord injury, Alzheimer's disease, premature birth, erectile dysfunction, endocrine dysfunctions, arteriosclerosis, prostatic hypertrophy, diabetes and complications of diabetes, metabolic syndrome, blood vessel restenosis, atherosclerosis, inflammation, autoimmune diseases, AIDS, osteopathy, infection of digestive tracts with bacteria, sepsis or cancer development and progression.
